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{{Infobox enzyme
| Name = Cocaine esterase
| EC_number = 3.1.1.84
| CAS_number = 
| IUBMB_EC_number = 3/1/1/84
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Cocaine esterase''' ({{EC number|3.1.1.84}}, ''CocE'', ''hCE2'', ''hCE-2'', ''human carboxylesterase 2'') is an [[enzyme]] with system name ''cocaine benzoylhydrolase''.<ref>{{cite journal | title = Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity |author = Gao, D., Narasimhan, D.L., Macdonald, J., Brim, R., Ko, M.C., Landry, D.W., Woods, J.H., Sunahara, R.K. and Zhan, C.G. |journal = Mol. Pharmacol. |year = 2009 |volume = 75 |pages = 318–323 |pmid = 18987161 |doi=10.1124/mol.108.049486 |issue=2}}</ref><ref>{{cite journal | title = Gene cloning and nucleotide sequencing and properties of a cocaine esterase from ''Rhodococcus'' sp. strain MB1 |author = Bresler, M.M., Rosser, S.J., Basran, A. and Bruce, N.C. |journal = Appl. Environ. Microbiol. |year = 2000 |volume = 66 |pages = 904–908 |pmid = 10698749 |issue=3}}</ref><ref>{{cite journal | title = Identification of a cocaine esterase in a strain of ''Pseudomonas maltophilia'' |author = Britt, A.J., Bruce, N.C. and Lowe, C.R. |journal = J. Bacteriol. |year = 1992 |volume = 174 |pages = 2087–2094 |pmid = 1551831 |issue=7}}</ref><ref>{{cite journal | title = Crystal structure of a bacterial cocaine esterase |author = Larsen, N.A., Turner, J.M., Stevens, J., Rosser, S.J., Basran, A., Lerner, R.A., Bruce, N.C. and Wilson, I.A. |journal = Nat. Struct. Biol. |year = 2002 |volume = 9 |pages = 17–21 |pmid = 11742345 |doi=10.1038/nsb742 |issue=1}}</ref><ref>{{cite journal | title = Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin |author = Pindel, E.V., Kedishvili, N.Y., Abraham, T.L., Brzezinski, M.R., Zhang, J., Dean, R.A. and Bosron, W.F. |journal = J. Biol. Chem. |year = 1997 |volume = 272 |pages = 14769–14775 |pmid = 9169443 |doi=10.1074/jbc.272.23.14769}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[cocaine]] + H<sub>2</sub>O <math>\rightleftharpoons</math> ecgonine methyl ester + [[benzoate]]

[[Rhodococcus]] sp. strain MB1 and [[Pseudomonas maltophilia]] strain MB11L can utilize cocaine as sole source of [[carbon]] and [[energy]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Cocaine+esterase}}

[[Category:EC 3.1.1]]