View source for Oligopeptide-transporting ATPase

{{enzyme
| Name = phosphoribosyl-ATP diphosphatase
| EC_number = 3.6.1.31
| CAS_number = 69553-55-5
| IUBMB_EC_number = 3/6/1/31
| GO_code = 0004636
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''phosphoribosyl-ATP diphosphatase''' ({{EC number|3.6.1.31}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:1-(5-phosphoribosyl)-ATP + H<sub>2</sub>O <math>\rightleftharpoons</math> 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[1-(5-phosphoribosyl)-ATP]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[1-(5-phosphoribosyl)-AMP]] and [[diphosphate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides in phosphorus-containing anhydrides.  The systematic name of this enzyme class is '''1-(5-phosphoribosyl)-ATP diphosphohydrolase'''. Other names in common use include '''phosphoribosyl-ATP pyrophosphatase''', and '''phosphoribosyladenosine triphosphate pyrophosphatase'''.  This enzyme participates in [[histidine metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[Hydron (chemistry)|H+]].  

==Structural studies==

As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1Y6X}}, {{PDB link|1YVW}}, {{PDB link|1YXB}}, and {{PDB link|2A7W}}.

==References==
{{reflist|1}}
* {{cite journal | author = Smith DWE and Ames BN | date = 1965 | title = Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis | journal = J. Biol. Chem.  | volume = 240 | pages = 3056&ndash;3063 | pmid=14342333}}

{{hydrolase-stub}}

[[Category:EC 3.6.1]]
[[Category:Enzymes of known structure]]