View source for Phosphatidylinositol-3,4-bisphosphate 4-phosphatase

{{enzyme
| Name = phosphoserine phosphatase
| EC_number = 3.1.3.3
| CAS_number = 9025-73-4
| IUBMB_EC_number = 3/1/3/3
| GO_code = 0004647
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''phosphoserine phosphatase''' ({{EC number|3.1.3.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:O-phospho-L(or D)-serine + H<sub>2</sub>O <math>\rightleftharpoons</math> L(or D)-serine + phosphate

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[O-phospho-L-serine]], [[O-phospho-D-serine]], and [[water|H<sub>2</sub>O]], whereas its 3 [[product (chemistry)|products]] are [[L-serine]], [[D-serine]], and [[phosphate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on phosphoric [[ester|monoester]] bonds.  The systematic name of this enzyme class is '''O-phosphoserine phosphohydrolase'''. This enzyme participates in [[glycine, serine and threonine metabolism]].  

==Structural studies==

As of late 2007, 12 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1F5S}}, {{PDB link|1J97}}, {{PDB link|1L7M}}, {{PDB link|1L7N}}, {{PDB link|1L7O}}, {{PDB link|1L7P}}, {{PDB link|1L8L}}, {{PDB link|1L8O}}, {{PDB link|1NNL}}, {{PDB link|2J6Y}}, {{PDB link|2J6Z}}, and {{PDB link|2J70}}.

==References==
{{reflist|1}}
* {{cite journal | author = BORKENHAGEN LF, KENNEDY EP | date = 1959 | title = The enzymatic exchange of L-serine with O-phospho-L-serine catalyzed by a specific phosphatase | journal = J. Biol. Chem.  | volume = 234 | pages = 849&ndash;53  | pmid = 13654276 | issue = 4 }}
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
* {{cite journal | author = Neuhaus FC and Byrne WL | date = 1959 | title = Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase | journal = J. Biol. Chem.  | volume = 234 | pages = 113&ndash;121 | pmid=13610904}}

{{hydrolase-stub}}

[[Category:EC 3.1.3]]
[[Category:Enzymes of known structure]]