View source for Phospho-N-acetylmuramoyl-pentapeptide-transferase

{{enzyme
| Name = protein-N(PI)-phosphohistidine-sugar phosphotransferase
| EC_number = 2.7.1.69
| CAS_number = 37278-09-4
| IUBMB_EC_number = 2/7/1/69
| GO_code = 0008982
| image = 
| width = 
| caption = 
}}

In [[enzymology]], a '''protein-Npi-phosphohistidine-sugar phosphotransferase''' ({{EC number|2.7.1.69}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:protein Npi-phospho-L-histidine + sugar <math>\rightleftharpoons</math> protein histidine + sugar phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[protein Npi-phospho-L-histidine]] and [[sugar]], whereas its two [[product (chemistry)|products]] are [[protein histidine]] and [[sugar phosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor.  The systematic name of this enzyme class is '''protein-Npi-phosphohistidine:sugar Npi-phosphotransferase'''. Other names in common use include '''glucose permease''', '''PTS permease''', '''phosphotransferase, phosphohistidinoprotein-hexose''', '''enzyme IIl4ac''', '''gene glC proteins''', '''gene bglC RNA formation factors''', '''PEP-dependent phosphotransferase enzyme II''', '''PEP-sugar phosphotransferase enzyme II''', '''phosphoenolpyruvate-sugar phosphotransferase enzyme II''', '''phosphohistidinoprotein-hexose phosphotransferase''', '''phosphohistidinoprotein-hexose phosphoribosyltransferase''', '''phosphoprotein factor-hexose phosophotransferase''', '''protein, specific or class, gene bglC''', '''ribonucleic acid formation factor, gene glC''', '''sucrose phosphotransferase system II''', and '''protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase'''.  This enzyme participates in 7 [[metabolism|metabolic pathways]]: [[glycolysis / gluconeogenesis]], [[Fructose metabolism|fructose]] and [[Mannose metabolism|mannose metabolism]], [[galactose metabolism]], [[ascorbate and aldarate metabolism]], [[starch and sucrose metabolism]], [[aminosugars metabolism]], and [[phosphotransferase system (pts)]].  

==Structural studies==

As of late 2007, 29 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1A3A}}, {{PDB link|1A6J}}, {{PDB link|1AX3}}, {{PDB link|1BLE}}, {{PDB link|1E2A}}, {{PDB link|1E2B}}, {{PDB link|1F3Z}}, {{PDB link|1GGR}}, {{PDB link|1GLA}}, {{PDB link|1GLB}}, {{PDB link|1GLC}}, {{PDB link|1GLD}}, {{PDB link|1GLE}}, {{PDB link|1GPR}}, {{PDB link|1H9C}}, {{PDB link|1IBA}}, {{PDB link|1IIB}}, {{PDB link|1NRZ}}, {{PDB link|1O2F}}, {{PDB link|1O53}}, {{PDB link|1PDO}}, {{PDB link|1TVM}}, {{PDB link|1VRC}}, {{PDB link|1WCR}}, {{PDB link|2A0J}}, {{PDB link|2E2A}}, {{PDB link|2F3G}}, {{PDB link|2FEW}}, and {{PDB link|2GPR}}.

==References==
{{reflist|1}}
* {{cite journal | author = Kornberg HL, Riordan C | date = 1976 | title = Uptake of galactose into Escherichia coli by facilitated diffusion | journal = J. Gen. Microbiol.  | volume = 94 | pages = 75&ndash;89  | pmid = 778334 | issue = 1 }}
* {{cite journal | author =  | date = 1976 | title = The bacterial phosphoenolpyruvate: sugar phosphotransferase system | journal = Biochim. Biophys. Acta.  | volume = 457 | pages = 213&ndash;57  | pmid = 187249 | issue =  3-4 }}

{{enzyme-stub}}

[[Category:EC 2.7.1]]
[[Category:Enzymes of known structure]]