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{{enzyme
| Name = succinate-semialdehyde dehydrogenase [NAD(P)+]
| EC_number = 1.2.1.16
| CAS_number = 37250-88-7
| IUBMB_EC_number = 1/2/1/16
| GO_code = 0009013
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''succinate-semialdehyde dehydrogenase [NAD(P)+]''' ({{EC number|1.2.1.16}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:succinate semialdehyde + NAD(P)+ + H<sub>2</sub>O <math>\rightleftharpoons</math> succinate + NAD(P)H + 2 H<sup>+</sup>

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[succinate semialdehyde]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]], whereas its 4 [[product (chemistry)|products]] are [[succinate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is '''succinate-semialdehyde:NAD(P)+ oxidoreductase'''. Other names in common use include '''succinate semialdehyde dehydrogenase (nicotinamide adenine''', '''dinucleotide (phosphate))''', and '''succinate-semialdehyde dehydrogenase [NAD(P)+]'''.  This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[glutamate metabolism]], [[tyrosine metabolism]], and [[butanoate metabolism]].  

==References==
{{reflist|1}}
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
* {{cite journal | author = JAKOBY WB, SCOTT EM | date = 1959 | title = Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase | journal = J. Biol. Chem.  | volume = 234 | pages = 937&ndash;40  | pmid = 13654295 | issue = 4 }}
* {{cite journal | author = Nirenberg MW and Jakoby WB | date = 1960 | title = Enzymatic utilization of gamma-hydroxybutyric acid | journal = J. Biol. Chem.  | volume = 235 | pages = 954&ndash;960 | pmid=14427301}}

{{1.2-enzyme-stub}}

[[Category:EC 1.2.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]