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{{Infobox enzyme
| Name = NADH:ubiquinone reductase (Na<sup>+</sup>-transporting)
| EC_number = 1.6.5.8
| CAS_number = 
| IUBMB_EC_number = 1/6/5/8
| GO_code = 
| image = 
| width = 
| caption =
}}
'''NADH:ubiquinone reductase (Na<sup>+</sup>-transporting)''' ({{EC number|1.6.5.8}}, ''Na<sup>+</sup>-translocating NADH-quinone reductase'', ''(Na<sup>+</sup>-NQR)'') is an [[enzyme]] with system name ''NADH:ubiquinone oxidoreductase (Na<sup>+</sup>-translocating)''.<ref>{{cite journal | title = Cloning and sequencing of four structural genes for the Na<small><sup>+</sup></small>-translocating NADH-ubiquinone oxidoreductase of <em>Vibrio alginolyticus</em> |author = Beattie, P., Tan, K., Bourne, R.M., Leach, D., Rich, P.R. and Ward, F.B. |journal = FEBS Lett. |year = 1994 |volume = 356 |pages = 333–338 |pmid = 7805867 |issue=2-3}}</ref><ref>{{cite journal | title = Identification of six subunits constituting Na<small><sup>+</sup></small>-translocating NADH-quinone reductase from the marine <em>Vibrio alginolyticus</em> |author = Nakayama, Y., Hayashi, M. and Unemoto, T. |journal = FEBS Lett. |year = 1998 |volume = 422 |pages = 240–242 |pmid = 9490015 |issue=2}}</ref><ref>{{cite journal | title = Sodium-dependent steps in the redox reactions of the Na<small><sup>+</sup></small>-motive NADH:quinone oxidoreductase from <em>Vibrio harveyi</em> |author = Bogachev, A.V., Bertsova, Y.V., Barquera, B. and Verkhovsky, M.I. |journal = Biochemistry |year = 2001 |volume = 40 |pages = 7318–7323 |pmid = 11401580 |issue=24}}</ref><ref>{{cite journal | title = Purification and characterization of the recombinant Na<small><sup>+</sup></small>-translocating NADH:quinone oxidoreductase from <em>Vibrio cholerae</em> |author = Barquera, B., Hellwig, P., Zhou, W., Morgan, J.E., Hase, C.C., Gosink, K.K., Nilges, M., Bruesehoff, P.J., Roth, A., Lancaster, C.R. and Gennis, R.B. |journal = Biochemistry |year = 2002 |volume = 41 |pages = 3781–3789 |pmid = 11888296 |issue=11}}</ref><ref>{{cite journal | title = Mutagenesis study of the 2Fe-2S center and the FAD binding site of the Na<small><sup>+</sup></small>-translocating NADH:ubiquinone oxidoreductase from <em>Vibrio cholerae</em> |author = Barquera, B., Nilges, M.J., Morgan, J.E., Ramirez-Silva, L., Zhou, W. and Gennis, R.B. |journal = Biochemistry |year = 2004 |volume = 43 |pages = 12322–12330 |pmid = 15379571 |doi=10.1021/bi048689y |issue=38}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: NADH + H<sup>+</sup> + ubiquinone + n Na<sup>+</sup>in <math>\rightleftharpoons</math> NAD+ + ubiquinol + n Na<sup>+</sup>out

This enzyme is iron-sulfur flavoprotein.

== References ==
{{reflist}}

== External links ==
* {{MeshName|NADH:ubiquinone+reductase+(Na+-transporting)}}

[[Category:EC 1.6.5]]