View source for TRNA-pseudouridine synthase I

{{enzyme
| Name = UDP-N-acetylglucosamine 4-epimerase
| EC_number = 5.1.3.7
| CAS_number = 9024-16-2
| IUBMB_EC_number = 5/1/3/7
| GO_code = 0003974
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''UDP-N-acetylglucosamine 4-epimerase''' ({{EC number|5.1.3.7}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:UDP-N-acetyl-D-glucosamine <math>\rightleftharpoons</math> UDP-N-acetyl-D-galactosamine

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[UDP-N-acetyl-D-glucosamine]], and one [[product (chemistry)|product]], [[UDP-N-acetyl-D-galactosamine]].

This enzyme belongs to the family of [[isomerase]]s, specifically those [[racemase]]s and [[epimerase]]s acting on [[carbohydrate]]s and derivatives.  The systematic name of this enzyme class is '''UDP-N-acetyl-D-glucosamine 4-epimerase'''. Other names in common use include '''UDP acetylglucosamine epimerase''', '''uridine diphosphoacetylglucosamine epimerase''', '''uridine diphosphate N-acetylglucosamine-4-epimerase''', and '''uridine 5'-diphospho-N-acetylglucosamine-4-epimerase'''.  This enzyme participates in [[aminosugars metabolism]].  

==Structural studies==

As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1SB8}} and {{PDB link|1SB9}}.

==References==
{{reflist|1}}
* {{cite journal | author = GLASER L | date = 1959 | title = The biosynthesis of N-acetylgalactosamine | journal = J. Biol. Chem.  | volume = 234 | pages = 2801&ndash;5  | pmid = 13828347 }}
* {{cite journal | author = Kornfeld S and Glaser L | date = 1962 | title = The synthesis of thymidine-linked sugars. V. Thymidine diphosphate-amino sugars | journal = J. Biol. Chem.  | volume = 237 | pages = 3052&ndash;3059 | pmid=14034827}}

{{isomerase-stub}}

[[Category:EC 5.1.3]]
[[Category:Enzymes of known structure]]