View source for TRNA (adenine57-N1/adenine58-N1)-methyltransferase

{{Infobox enzyme
| Name = 23S rRNA (adenosine<sup>1067</sup>-2'-O)-methyltransferase
| EC_number = 2.1.1.230
| CAS_number = 
| IUBMB_EC_number = 2/1/1/230
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (adenosine<sup>1067</sup>-2'-O)-methyltransferase''' ({{EC number|2.1.1.230}}, ''23S rRNA A1067 2'-methyltransferase'', ''thiostrepton-resistance methylase'', ''nosiheptide-resistance methyltransferase'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (adenosine<sup>1067</sup>-2'-O)-methyltransferase''.<ref>{{cite journal | title = Overexpression of the thiostrepton-resistance gene from ''Streptomyces azureus'' in ''Escherichia coli'' and characterization of recognition sites of the 23S rRNA A<sup>1067</sup> 2&prime;-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA |author = Bechthold, A. and Floss, H.G. |journal = Eur. J. Biochem. |year = 1994 |volume = 224 |pages = 431–437 |pmid = 7925357}}</ref><ref>{{cite journal | title = Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton |author = Thompson, J., Schmidt, F. and Cundliffe, E. |journal = J. Biol. Chem. |year = 1982 |volume = 257 |pages = 7915–7917 |pmid = 6806287}}</ref><ref>{{cite journal | title = Purification and properties of an RNA methylase produced by ''Streptomyces azureus'' and involved in resistance to thiostrepton |author = Thompson, J. and Cundliffe, E. |journal = J. Gen. Microbiol. |year = 1981 |volume = 124 |pages = 291–297 |pmid = }}</ref><ref>{{cite journal | title = Crystal structure of the nosiheptide-resistance methyltransferase of ''Streptomyces actuosus'' |author = Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A.I. and Xu, Y. |journal = Biochemistry |year = 2010 |volume = 49 |pages = 6440–6450 |pmid = 20550164}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[adenosine]]<sup>1067</sup> in 23S rRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + 2'-O-methyladenosine<sup>1067</sup> in 23S rRNA

The methylase that is responsible for autoimmunity in the [[thiostrepton]] producer ''[[Streptomyces azureus]]''.

== References ==
{{reflist}}

== External links ==
* {{MeshName|23S+rRNA+(adenosine1067-2'-O)-methyltransferase}}

[[Category:EC 2.1.1]]