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{{Infobox enzyme
| Name = N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase
| EC_number = 2.4.1.165
| CAS_number = 109136-50-7
| IUBMB_EC_number = 2/4/1/165
| GO_code = 
| image = 
| width = 
| caption =
}}
'''N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase''' ({{EC number|2.4.1.165}}, ''uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase'', ''UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase'') is an [[enzyme]] with system name ''UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase''.<ref>{{cite journal | title = Biosynthesis of a globoside-type glycosphingolipid by a &beta;-''N''-acetylgalactosaminyltransferase from embryonic chicken brain |author = Chien, J.-L., Williams, T. and Basu, S. |journal = J. Biol. Chem. |year = 1973 |volume = 248 |pages = 1778–1785 |pmid = 4632917 |issue=5}}</ref><ref>{{cite journal | title = Identification of a &alpha;-NeuAc-(2-3)-&beta;-D-galactopyranosyl ''N''-acetyl-&beta;-D-galactosaminyltransferase in human kidney |author = Piller, F., Blanchard, D., Huet, M. and Cartron, J.-P. |journal = Carbohydr. Res. |year = 1986 |volume = 149 |pages = 171–184 |pmid = 2425965 |doi=10.1016/S0008-6215(00)90376-8}}</ref><ref>{{cite journal | title = Identification and characterization of UDP-GalNAc: NeuAc &alpha;2-3Gal &beta;1-4Glc(NAc) &beta;1-4(GalNAc to Gal)''N''-acetylgalactosaminyltransferase in human blood plasma |author = Takeya, A., Hosomi, O. and Kogure, T. |journal = J. Biochem. (Tokyo) |year = 1987 |volume = 101 |pages = 251–259 |pmid = 3106337 |issue=1}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[UDP-N-acetyl-D-galactosamine]] + N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <math>\rightleftharpoons</math> UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

This enzyme requires Mn<sup>2+</sup>.

== References ==
{{reflist}}

== External links ==
* {{MeshName|N-acetylneuraminylgalactosylglucosylceramide+beta-1,4-N-acetylgalactosaminyltransferase}}

[[Category:EC 2.4.1]]