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{{Infobox enzyme
| Name = Squalene—-hopanol cyclase
| EC_number = 4.2.1.129
| CAS_number = 
| IUBMB_EC_number = 4/2/1/129
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Squalene—-hopanol cyclase''' ({{EC number|4.2.1.129}}, ''squalene—-hopene cyclase'') is an [[enzyme]] with system name ''hopan-22-ol hydro-lyase''.<ref>{{cite journal | title = Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3''R'',''S'')-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring |author = Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. |journal = Org Biomol Chem |year = 2004 |volume = 2 |pages = 1456–1470 |pmid = 15136801}}</ref><ref>{{cite journal | title = Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from ''Alicyclobacillus acidocaldarius'' |author = Sato, T., Kouda, M. and Hoshino, T. |journal = Biosci. Biotechnol. Biochem. |year = 2004 |volume = 68 |pages = 728–738 |pmid = 15056909}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: hopan-22-ol <math>\rightleftharpoons</math> [[squalene]] + H<sub>2</sub>O

The enzyme produces the cyclization products [[hopene]] and [[hopanol]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Squalene---hopanol+cyclase}}

{{DEFAULTSORT:Squalene--hopanol cyclase}}
[[Category:EC 4.2.1]]