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{{enzyme
| Name = 4-chlorobenzoate dehalogenase
| EC_number = 3.8.1.6
| CAS_number = 94047-11-7
| IUBMB_EC_number = 3/8/1/6
| GO_code = 0047576
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''4-chlorobenzoate dehalogenase''' ({{EC number|3.8.1.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:4-chlorobenzoate + H<sub>2</sub>O <math>\rightleftharpoons</math> 4-hydroxybenzoate + chloride

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[4-chlorobenzoate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[4-hydroxybenzoate]] and [[chloride]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on halide bonds in carbon-halide compounds.  The systematic name of this enzyme class is '''4-chlorobenzoate chlorohydrolase'''. This enzyme is also called '''halobenzoate dehalogenase'''.

==Structural studies==

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1BVQ}}, {{PDB link|1JXZ}}, and {{PDB link|1NZY}}.

==References==
{{reflist|1}}
* {{cite journal | author = Muller R, Thiele J, Klages U, Lingens F | year = 1984 | title = Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3 | journal = Biochem. Biophys. Res. Commun.  | volume = 124 | pages = 178&ndash;82  | pmid = 6497878 | doi = 10.1016/0006-291X(84)90933-1 | issue = 1 }}
* {{cite journal | author = Heppel LA and Porterfield VT | year = 1948 | title = Enzymatic dehalogenation of certain brominated and chlorinated compounds | journal = J. Biol. Chem.  | volume = 176 | issue = 2 | pages = 763&ndash;769 | pmid=18889931}}

[[Category:EC 3.8.1]]
[[Category:Enzymes of known structure]]


{{hydrolase-stub}}