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| Name = 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
| EC_number = 3.5.1.66
| CAS_number = 95829-26-8
| IUBMB_EC_number = 3/5/1/66
| GO_code = 0047414
| image =
| width =
| caption =
}}
In [[enzymology]], a '''2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase''' ({{EC number|3.5.1.66}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H<sub>2</sub>O <math>\rightleftharpoons</math> acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH<sub>3</sub> + CO<sub>2</sub>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[2-(hydroxymethyl)-3-(acetamidomethylene)succinate]] and [[water|H<sub>2</sub>O]], whereas its 4 [[product (chemistry)|products]] are [[acetate]], [[2-(hydroxymethyl)-4-oxobutanoate]], [[ammonia|NH<sub>3</sub>]], and [[carbon dioxide|CO<sub>2</sub>]].
 
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is '''2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)'''. Other names in common use include '''compound B hydrolase''', '''alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid''', and '''hydrolase'''. This enzyme participates in [[vitamin B6|vitamin B<sub>6</sub> metabolism]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Huynh MS, Snell EE | date = 1985 | title = Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases | journal = J. Biol. Chem. | volume = 260 | pages = 2379&ndash;83  | pmid = 3972793 | issue = 4 }}
 
{{hydrolase-stub}}
 
[[Category:EC 3.5.1]]
[[Category:Hydrolases acting on nonpeptide C-N bonds]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 23:55, 9 January 2013

Template:Enzyme In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2

Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin B6 metabolism.

References

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