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{{enzyme
| Name = lovastatin nonaketide synthase
| EC_number = 2.3.1.161
| CAS_number = 235426-97-8
| IUBMB_EC_number = 2/3/1/161
| GO_code = 0050637
| image =
| width =
| caption =
}}
In [[enzymology]], '''lovastatin nonaketide synthase''' ({{EC number|2.3.1.161}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H<sup>+</sup> + S-adenosyl-L-methionine <math>\rightleftharpoons</math> dihydromonacolin L + 9 CoA + 8 CO<sub>2</sub> + 11 NADP<sup>+</sup> + S-adenosyl-L-homocysteine + 6 H<sub>2</sub>O
 
The 5 [[substrate (biochemistry)|substrates]] of this enzyme are [[acetyl-CoA]], [[malonyl-CoA]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[S-adenosyl-L-methionine]], whereas its 6 [[product (chemistry)|products]] are [[dihydromonacolin L]], [[coenzyme A|CoA]], [[carbon dioxide|CO<sub>2</sub>]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], [[S-adenosyl-L-homocysteine]], and [[water|H<sub>2</sub>O]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)'''.  
 
==References==
{{reflist|1}}
* {{cite journal | author = Heever JP, Hutchinson CR and Vederas JC | date = 2000 | title = Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue | journal = J. Am. Chem. Soc. | volume = 122 | pages = 11519&ndash;11520 | doi = 10.1021/ja003216 | issue = 46 }}
 
{{transferase-stub}}
 
[[Category:EC 2.3.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 21:47, 17 March 2013

Template:Enzyme In enzymology, lovastatin nonaketide synthase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H+, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO2, NADP+, S-adenosyl-L-homocysteine, and H2O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

References

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