Aldose beta-D-fructosyltransferase: Difference between revisions

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{{enzyme
| Name = alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
| EC_number = 2.4.99.8
| CAS_number = 67339-00-8
| IUBMB_EC_number = 2/4/99/8
| GO_code = 0003828
| image =
| width =
| caption =
}}
In [[enzymology]], an '''alpha-N-acetylneuraminate alpha-2,8-sialyltransferase''' ({{EC number|2.4.99.8}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R <math>\rightleftharpoons</math> CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D- galactosyl-R
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[CMP-N-acetylneuraminate]] and [[alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R]], whereas its 3 [[product (chemistry)|products]] are [[cytidine monophosphate|CMP]], [[alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-]], and [[galactosyl-R]]. This enzyme participates in 4 [[metabolism|metabolic pathways]]: [[glycosphingolipid biosynthesis - neo-lactoseries]], [[glycosphingolipid biosynthesis - globoseries]], [[glycosphingolipid biosynthesis - ganglioseries]], and [[glycan structures - biosynthesis 2]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[glycosyltransferase]]s that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is '''CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactos ide alpha-2,8-N-acetylneuraminyltransferase'''. Other names in common use include '''cytidine monophosphoacetylneuraminate-ganglioside GM3''', '''alpha-2,8-sialyltransferase''', '''ganglioside GD3 synthase''', '''ganglioside GD3 synthetase sialyltransferase''', '''CMP-NeuAc:LM1(alpha2-8) sialyltranferase''', '''GD3 synthase''', and '''SAT-2'''.
 
==References==
{{reflist|1}}
*{{cite journal | author = Eppler CM, Morre DJ, Keenan TW | year = 1980 | title = Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides | journal = Biochim. Biophys. Acta. | volume = 619 | pages = 332–43 | pmid = 7407217 | issue = 2 | doi = 10.1016/0005-2760(80)90081-8 }}
*{{cite journal | author = Higashi H, Basu M, Basu S | year = 1985 | title = Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain | journal = J. Biol. Chem. | volume = 260 | pages = 824–8  | pmid = 3838172 | issue = 2 }}
*{{cite journal | author = McCoy RD, Vimr ER, Troy FA | year = 1985 | title = CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules | journal = J. Biol. Chem. | volume = 260 | pages = 12695–9  | pmid = 4044605 | issue = 23 }}
*{{cite journal | author = Yohe HC, Yu RK | year = 1980 | title = In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a | journal = J. Biol. Chem. | volume = 255 | pages = 608–13  | pmid = 6766128 | issue = 2 }}
 
[[Category:EC 2.4.99]]
[[Category:Enzymes of unknown structure]]
 
 
{{enzyme-stub}}

Latest revision as of 01:54, 14 October 2013

Template:Enzyme In enzymology, an alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D- galactosyl-R

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-, and galactosyl-R. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, glycosphingolipid biosynthesis - ganglioseries, and glycan structures - biosynthesis 2.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactos ide alpha-2,8-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-ganglioside GM3, alpha-2,8-sialyltransferase, ganglioside GD3 synthase, ganglioside GD3 synthetase sialyltransferase, CMP-NeuAc:LM1(alpha2-8) sialyltranferase, GD3 synthase, and SAT-2.

References

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  • One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang


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