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{{enzyme
| Name = [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase
| EC_number = 2.7.11.4
| CAS_number = 82391-38-6
| IUBMB_EC_number = 2/7/11/4
| GO_code = 0047323
| image =
| width =  
| caption =  
}}
In [[enzymology]], a '''[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]''' ({{EC number|2.7.11.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] <math>\rightleftharpoons</math> ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]], and [[phosphate]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring a phosphate group to the sidechain [[oxygen]] atom of [[serine]] or [[threonine]] residues in [[protein]]s ([[protein-serine/threonine kinase]]s). The systematic name of this enzyme class is '''ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase'''. Other names in common use include '''kinase''', '''BCK''', '''BCKD kinase''', '''BCODH kinase''', '''branched-chain alpha-ketoacid dehydrogenase kinase''', '''branched-chain 2-oxo acid dehydrogenase kinase''', '''branched-chain keto acid dehydrogenase kinase''', '''branched-chain oxo acid dehydrogenase kinase (phosphorylating)''', and '''STK2'''.   
 
In 2012, it was suggested that mutations in the gene which expresses this enzyme could be the cause of a rare form of autism.<ref>{{cite doi|10.1126/science.1224631}}</ref>
 
 
==References==
{{reflist|1}}
* {{cite journal | author = Paxton R, Harris RA | date = 1982 | title = Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation | journal = J. Biol. Chem. | volume = 257 | pages = 14433&ndash;9  | pmid = 7142221 | issue = 23 }}
* {{cite journal | author = Wynn RM, Chuang JL, Cote CD, Chuang DT | date = 2000 | title = Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase | journal = J. Biol. Chem. | volume = 275 | pages = 30512&ndash;9  | pmid = 10903321 | doi = 10.1074/jbc.M005075200 | issue = 39 }}
* {{cite journal | author = Chuang JL, Wynn RM, Chuang DT | date = 2002 | title = The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase | journal = J. Biol. Chem| volume = 277 | pages = 36905&ndash;8  | pmid = 12189132 | doi = 10.1074/jbc.C200430200 | issue = 40 }}
* {{cite journal | author = Popov KM, Hawes JW, Harris RA | date = 1997 | title = Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases | journal = Adv. Second. Messenger. Phosphoprotein. Res.  | volume = 31 | pages = 105&ndash;11 | pmid = 9344245 | doi = 10.1016/S1040-7952(97)80012-2 | series = Advances in Second Messenger and Phosphoprotein Research | isbn = 9780120361311 }}
 
 
[[Category:EC 2.7.11]]
[[Category:Enzymes of unknown structure]]
 
 
{{enzyme-stub}}

Latest revision as of 22:01, 16 December 2013

Template:Enzyme In enzymology, a [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate

Thus, the two substrates of this enzyme are ATP and 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring), whereas its 3 products are ADP, 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring), and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase. Other names in common use include kinase, BCK, BCKD kinase, BCODH kinase, branched-chain alpha-ketoacid dehydrogenase kinase, branched-chain 2-oxo acid dehydrogenase kinase, branched-chain keto acid dehydrogenase kinase, branched-chain oxo acid dehydrogenase kinase (phosphorylating), and STK2.

In 2012, it was suggested that mutations in the gene which expresses this enzyme could be the cause of a rare form of autism.[1]


References

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    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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