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| {{enzyme
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| | Name = 2-hydroxyquinoline 8-monooxygenase
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| | EC_number = 1.14.13.61
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| | CAS_number =
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| | IUBMB_EC_number = 1/14/13/61
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| | GO_code =
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| In [[enzymology]], a '''2-hydroxyquinoline 8-monooxygenase''' ({{EC number|1.14.13.61}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :quinolin-2-ol + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> quinolin-2,8-diol + NAD<sup>+</sup> + H<sub>2</sub>O
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| The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[quinolin-2-ol]], [[nicotinamide adenine dinucleotide|NADH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[quinolin-2,8-diol]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[water|H<sub>2</sub>O]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is '''quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating)'''. This enzyme is also called '''2-oxo-1,2-dihydroquinoline 8-monooxygenase'''. It employs one [[cofactor (biochemistry)|cofactor]], [[iron]].
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| ==Structural studies==
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| As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1Z01}}, {{PDB link|1Z02}}, and {{PDB link|1Z03}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Rosche B, Tshisuaka B, Fetzner S, Lingens F | date = 1995 | title = 2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86 | journal = J. Biol. Chem. | volume = 270 | pages = 17836–42 | pmid = 7629085 | doi = 10.1074/jbc.270.30.17836 | issue = 30 }}
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| {{1.14.13-enzyme-stub}}
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| [[Category:EC 1.14.13]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Iron enzymes]]
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| [[Category:Enzymes of known structure]]
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