3-dehydroquinate synthase: Difference between revisions

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{{enzyme
| Name = 5-dehydro-4-deoxyglucarate dehydratase
| EC_number = 4.2.1.41
| CAS_number = 37290-77-0
| IUBMB_EC_number = 4/2/1/41
| GO_code = 0047448
| image =
| width =
| caption =
}}


In [[enzymology]], a '''5-dehydro-4-deoxyglucarate dehydratase''' ({{EC number|4.2.1.41}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:5-dehydro-4-deoxy-D-glucarate <math>\rightleftharpoons</math> 2,5-dioxopentanoate + H<sub>2</sub>O + CO<sub>2</sub>
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Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[5-dehydro-4-deoxy-D-glucarate]], but three [[product (chemistry)|products]]: [[2,5-dioxopentanoate]], [[water|H<sub>2</sub>O]], and [[carbon dioxide|CO<sub>2</sub>]].
 
==Enzyme class==
This enzyme belongs to the family of [[lyase]]s, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is '''5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating 2,5-dioxopentanoate-forming)'''. Other names in common use include '''5-keto-4-deoxy-glucarate dehydratase''', '''5-keto-4-deoxy-glucarate dehydratase''', '''deoxyketoglucarate dehydratase''', '''D-4-deoxy-5-ketoglucarate hydro-lyase''', and '''5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)'''. This enzyme participates in [[ascorbate and aldarate metabolism]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Jeffcoat R, Hassall H, Dagley S | date=  1969 | title = Purification and properties of D-4-deoxy-5-oxoglucarate hydro-lyase (decarboxylating) | journal = Biochem. J. | volume = 115 | pages = 977&ndash;83  | pmid = 4982840 | issue = 5 | pmc = 1185240 }}
 
{{4.2-enzyme-stub}}
 
[[Category:EC 4.2.1]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 14:39, 18 October 2014


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