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| {{enzyme
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| | Name = 15-oxoprostaglandin 13-oxidase
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| | EC_number = 1.3.1.48
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| | CAS_number = 57406-74-3
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| | IUBMB_EC_number = 1/3/1/48
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| | GO_code = 0047522
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| In [[enzymology]], a '''15-oxoprostaglandin 13-oxidase''' ({{EC number|1.3.1.48}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ <math>\rightleftharpoons</math> (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase'''. Other names in common use include '''15-oxo-Delta13-prostaglandin reductase''', '''Delta13-15-ketoprostaglandin reductase''', '''15-ketoprostaglandin Delta13-reductase''', '''prostaglandin Delta13-reductase''', '''prostaglandin 13-reductase''', and '''15-ketoprostaglandin Delta13-reductase'''.
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| ==Structural studies==
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| As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1V3T}}, {{PDB link|1V3U}}, {{PDB link|1V3V}}, and {{PDB link|2DM6}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Hansen HS | date = 1982 | title = Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung | journal = Methods Enzymol. | volume = 86 | pages = 156–63 | pmid = 6290839 | doi = 10.1016/0076-6879(82)86186-7 }}
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| * {{cite journal | author = Jarabak J | date = 1982 | title = Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta | journal = Methods Enzymol. | volume = 86 | pages = 163–7 | pmid = 7132753 | doi = 10.1016/0076-6879(82)86187-9 }}
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| {{1.3-enzyme-stub}}
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| [[Category:EC 1.3.1]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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