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| {{enzyme
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| | Name = alkanal monooxygenase (FMN-linked)
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| | EC_number = 1.14.14.3
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| | CAS_number = 9014-00-0
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| | IUBMB_EC_number = 1/14/14/3
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| | GO_code = 0047646
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| In [[enzymology]], an '''alkanal monooxygenase (FMN-linked)''' ({{EC number|1.14.14.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :RCHO + reduced FMN + O<sub>2</sub> <math>\rightleftharpoons</math> RCOOH + FMN + H<sub>2</sub>O + hnu
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[RCHO]], [[reduced FMN]], and [[oxygen|O<sub>2</sub>]], whereas its 4 [[product (chemistry)|products]] are [[RCOOH]], [[flavin mononucleotide|FMN]], [[water|H<sub>2</sub>O]], and [[hn]]{{disambiguation needed|date=August 2013}}.
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is '''alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)'''. Other names in common use include '''bacterial luciferase''', '''aldehyde monooxygenase''', '''luciferase''', and '''Vibrio fischeri luciferase'''.
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| ==Structural studies==
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| As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1BRL}}, {{PDB link|1BSL}}, {{PDB link|1LUC}}, and {{PDB link|1XKJ}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Hastings JW | last2 = Nealson | year = 1978 | first2 = Kenneth H. | title = Bacterial bioluminescence light emission in the mixed function oxidation of reduced flavin and fatty aldehyde | journal = CRC. Crit. Rev. Biochem. | volume = 5 | pages = 163–84 | pmid = 363350 | doi = 10.3109/10409237809177143 | issue = 2 }}
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| * {{cite journal | author = Hastings JW, Nealson KH | year = 1977 | title = Bacterial bioluminescence | journal = Annu. Rev. Microbiol. | volume = 31 | pages = 549–95 | pmid = 199107 | doi = 10.1146/annurev.mi.31.100177.003001 }}
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| * {{cite journal | author = Hastings JW, Presswood RP | year = 1978 | title = Bacterial luciferase: FMNH2-aldehyde oxidase | journal = Methods Enzymol. | volume = 53 | pages = 558–70 | pmid = 309549 | doi = 10.1016/S0076-6879(78)53057-7 | series = Methods in Enzymology | isbn = 978-0-12-181953-8 }}
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| * {{cite journal | author = Nealson KH, Hastings JW | year = 1979 | title = Bacterial bioluminescence: its control and ecological significance | journal = Microbiol. Rev. | volume = 43 | pages = 496–518 | pmid = 396467 | issue = 4 | pmc = 281490 }}
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| * {{cite journal | author = Suzuki K, Kaidoh T, Katagiri M and Tsuchiya T | year = 1983 | title = O2 incorporation into a long-chain fatty-acid during bacterial luminescence | journal = Biochim. Biophys. Acta | volume = 722 | pages = 297–301 }}
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| [[Category:EC 1.14.14]]
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| [[Category:Enzymes of known structure]]
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| {{1.14-enzyme-stub}}
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