Glucarate O-hydroxycinnamoyltransferase: Difference between revisions

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{{enzyme
| Name = glutathione gamma-glutamylcysteinyltransferase
| EC_number = 2.3.2.15
| CAS_number = 125390-02-5
| IUBMB_EC_number = 2/3/2/15
| GO_code = 0016756
| image =
| width =
| caption =
}}
In [[enzymology]], a '''glutathione gamma-glutamylcysteinyltransferase''' ({{EC number|2.3.2.15}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:glutathione + [Glu(-Cys)]n-Gly <math>\rightleftharpoons</math> Gly + [Glu(-Cys)]n<sup>+</sup>1-Gly
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[glutathione]] and [Glu(-Cys)]n-Gly, whereas its two [[product (chemistry)|products]] are [[Gly]] and [Glu(-Cys)]n+1-Gly.
 
This enzyme belongs to the family of [[transferase]]s, specifically the [[aminoacyltransferase]]s. The systematic name of this enzyme class is '''glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase'''. Other names in common use include '''phytochelatin synthase''', and '''gamma-glutamylcysteine dipeptidyl transpeptidase'''.
 
==Structural studies==
 
As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2BTW}} and {{PDB link|2BU3}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Grill E, Loffler S, Winnacker E-L and Zenk MH | date = 1989 | title = Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase) | journal = Proc. Natl. Acad. Sci. USA | volume = 86 | pages = 6838&ndash;6842 | doi = 10.1073/pnas.86.18.6838 | issue = 18 }}
 
{{transferase-stub}}
 
[[Category:EC 2.3.2]]
[[Category:Enzymes of known structure]]

Latest revision as of 21:40, 17 March 2013

Template:Enzyme In enzymology, a glutathione gamma-glutamylcysteinyltransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

glutathione + [Glu(-Cys)]n-Gly Gly + [Glu(-Cys)]n+1-Gly

Thus, the two substrates of this enzyme are glutathione and [Glu(-Cys)]n-Gly, whereas its two products are Gly and [Glu(-Cys)]n+1-Gly.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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