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{{enzyme
| Name = naringenin-chalcone synthase
| EC_number = 2.3.1.74
| CAS_number = 56803-04-4
| IUBMB_EC_number = 2/3/1/74
| GO_code = 0016210
| image =
| width =
| caption =
}}
In [[enzymology]], a '''naringenin-chalcone synthase''' ({{EC number|2.3.1.74}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:3 malonyl-CoA + 4-coumaroyl-CoA <math>\rightleftharpoons</math> 4 CoA + naringenin chalcone + 3 CO<sub>2</sub>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[malonyl-CoA]] and [[4-coumaroyl-CoA]], whereas its 3 [[product (chemistry)|products]] are [[coenzyme A|CoA]], [[naringenin chalcone]], and [[carbon dioxide|CO<sub>2</sub>]].
 
This enzyme belongs to the family of [[transferase]]s, to be specific those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)'''. Other names in common use include '''chalcone synthase''', '''flavanone synthase''', '''6'-deoxychalcone synthase''', '''chalcone synthetase''', '''DOCS''', and '''CHS'''. This enzyme participates in [[flavonoid biosynthesis]].
 
==Structural studies==
 
As of late 2007, 21 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1BI5}}, {{PDB link|1BQ6}}, {{PDB link|1CGK}}, {{PDB link|1CGZ}}, {{PDB link|1CHW}}, {{PDB link|1CML}}, {{PDB link|1D6F}}, {{PDB link|1D6H}}, {{PDB link|1D6I}}, {{PDB link|1EE0}}, {{PDB link|1I86}}, {{PDB link|1I88}}, {{PDB link|1I89}}, {{PDB link|1I8B}}, {{PDB link|1JWX}}, {{PDB link|1QLV}}, {{PDB link|1TED}}, {{PDB link|1TEE}}, {{PDB link|1U0V}}, {{PDB link|1U0W}}, and {{PDB link|2P0U}}.
 
== References ==
{{reflist|1}}
* {{cite journal | author = Ayabe S, Udagawa A, Furuya T | date = 1988 | title = NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract | journal = Arch. Biochem. Biophys. | volume = 261 | pages = 458&ndash;62  | pmid = 3355160 | doi = 10.1016/0003-9861(88)90362-1 | issue = 2 }}
* {{cite journal | author = Heller W, Hahlbrock K | date = 1980 | title = Highly purified &quot;flavanone synthase&quot; from parsley catalyzes the formation of naringenin chalcone | journal = Arch. Biochem. Biophys. | volume = 200 | pages = 617&ndash;9  | pmid = 7436427 | doi = 10.1016/0003-9861(80)90395-1 | issue = 2 }}
 
[[Category:EC 2.3.1]]
[[Category:Enzymes of known structure]]
[[Category:Dihydrochalcones metabolism]]
 
{{transferase-stub}}

Latest revision as of 21:48, 17 March 2013

Template:Enzyme In enzymology, a naringenin-chalcone synthase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA 4 CoA + naringenin chalcone + 3 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, naringenin chalcone, and CO2.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include chalcone synthase, flavanone synthase, 6'-deoxychalcone synthase, chalcone synthetase, DOCS, and CHS. This enzyme participates in flavonoid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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Template:Transferase-stub