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| {{enzyme
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| | Name = gluconate 5-dehydrogenase
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| | EC_number = 1.1.1.69
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| | CAS_number = 9028-70-0
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| | IUBMB_EC_number = 1/1/1/69
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| | GO_code = 0008874
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| In [[enzymology]], a '''gluconate 5-dehydrogenase''' ({{EC number|1.1.1.69}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :D-gluconate + NAD(P)<sup>+</sup> <math>\rightleftharpoons</math> 5-dehydro-D-gluconate + NAD(P)H + H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[D-gluconate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[5-dehydro-D-gluconate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''D-gluconate:NAD(P)<sup>+</sup> 5-oxidoreductase'''. Other names in common use include '''5-keto-D-gluconate 5-reductase''', '''5-keto-D-gluconate 5-reductase''', '''5-ketogluconate 5-reductase''', '''5-ketogluconate reductase''', and '''5-keto-D-gluconate reductase'''.
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| ==Structural studies==
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| As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1VL8}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Ameyama M and Adachi O | year = 1982 | title = 5-Keto-D-gluconate reductase from ''Gluconobacter suboxydans'' | journal = Methods Enzymol. | volume = 89 | pages = 198–202 | doi = 10.1016/S0076-6879(82)89035-6 | series = Methods in Enzymology | isbn = 978-0-12-181989-7 }}
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| * {{cite journal | author = Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM | year = 2006 | title = A proteomic analysis of arsenical drug resistance in ''Trypanosoma brucei'' | journal = Proteomics | volume = 6 | pages = 2726–32 | pmid = 16526094 | doi = 10.1002/pmic.200500419 | issue = 9 }}
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| * {{cite journal | author = Okamoto K | date = Tokyo | title = Enzymic studies on the formation of 5-ketogluconic acid by ''Acetobacter suboxydans''. II. 5-Ketogluconate reductase | journal = J. Biochem. | pages = 448–52 | pmid=13939777}}
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| [[Category:EC 1.1.1]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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