N-methyl nucleosidase: Difference between revisions

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{{enzyme
| Name = ribosylpyrimidine nucleosidase
| EC_number = 3.2.2.8
| CAS_number = 37288-60-1
| IUBMB_EC_number = 3/2/2/8
| GO_code = 0050263
| image =
| width =
| caption =
}}
In [[enzymology]], a '''ribosylpyrimidine nucleosidase''' ({{EC number|3.2.2.8}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:a pyrimidine nucleoside + H<sub>2</sub>O <math>\rightleftharpoons</math> D-ribose + a pyrimidine base
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[pyrimidine nucleoside]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[D-ribose]] and [[pyrimidine base]].
 
This enzyme belongs to the family of [[hydrolase]]s, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is '''pyrimidine-nucleoside ribohydrolase'''. Other names in common use include '''N-ribosylpyrimidine nucleosidase''', '''pyrimidine nucleosidase''', '''N-ribosylpyrimidine ribohydrolase''', '''pyrimidine nucleoside hydrolase''', '''RihB''', '''YeiK''', and '''nucleoside ribohydrolase'''. This enzyme participates in [[purine metabolism]] and [[pyrimidine metabolism]].   
 
==Structural studies==
 
As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1Q8F}} and {{PDB link|1YOE}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Terada M, Tatibana M, Hayaishi O | date = 1967 | title = Purification and properties of nucleoside hydrolase from Pseudomonas fluorescens | journal = [[J. Biol. Chem.]]  | volume = 242 | pages = 5578&ndash;85  | pmid = 12325375 | issue = 23 }}
* {{cite journal | author = Petersen C, Moller LB | date = 2001 | title = The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation | journal = [[J. Biol. Chem.]]  | volume = 276 | pages = 884&ndash;94 | pmid = 11027694 | doi = 10.1074/jbc.M008300200 | issue = 2 }}
* {{cite journal | author = Giabbai B, Degano M | date = 2004 | title = Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK | journal = [[Acta Crystallogr. D]] | volume = 60 | pages = 524&ndash;7  | pmid = 14993681 | doi = 10.1107/S0907444903028488 | issue = Pt 3 }}
* {{cite journal | author = Giabbai B, Degano M | date = 2004 | title = Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy | journal = [[Structure (journal)|Structure]] | volume = 12 | pages = 739&ndash;49  | pmid = 15130467 | doi = 10.1016/j.str.2004.03.018 | issue = 5 }}
 
{{hydrolase-stub}}
 
[[Category:EC 3.2.2]]
[[Category:Enzymes of known structure]]

Revision as of 07:01, 14 April 2013

Template:Enzyme In enzymology, a ribosylpyrimidine nucleosidase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

a pyrimidine nucleoside + H2O D-ribose + a pyrimidine base

Thus, the two substrates of this enzyme are pyrimidine nucleoside and H2O, whereas its two products are D-ribose and pyrimidine base.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is pyrimidine-nucleoside ribohydrolase. Other names in common use include N-ribosylpyrimidine nucleosidase, pyrimidine nucleosidase, N-ribosylpyrimidine ribohydrolase, pyrimidine nucleoside hydrolase, RihB, YeiK, and nucleoside ribohydrolase. This enzyme participates in purine metabolism and pyrimidine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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Template:Hydrolase-stub