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{{enzyme
| Name = 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
| EC_number = 2.7.1.148
| CAS_number =
| IUBMB_EC_number = 2/7/1/148
| GO_code = 0050515
| image =
| width =
| caption =
}}
In [[enzymology]], a '''4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase''' ({{EC number|2.7.1.148}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol <math>\rightleftharpoons</math> ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor.  The systematic name of this enzyme class is '''ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase'''. This enzyme is also called '''CDP-ME kinase'''. This enzyme participates in [[biosynthesis of steroids]].
 
==Structural studies==
 
As of late 2007, 7 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1OJ4}}, {{PDB link|1UEK}}, {{PDB link|2V2Q}}, {{PDB link|2V2V}}, {{PDB link|2V2Z}}, {{PDB link|2V34}}, and {{PDB link|2V8P}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W | date = 2000 | title = Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-d-erythritol | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | pages = 1062&ndash;7  | pmid = 10655484 | doi = 10.1073/pnas.97.3.1062 | issue = 3 | pmc = 15522 }}
* {{cite journal | author = Seto H | date = 2000 | title = Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | journal = Tetrahedron Lett. | volume = 41 | pages = 2925&ndash;2928 | doi = 10.1016/S0040-4039(00)00295-1 | issue = 16 }}
 
{{enzyme-stub}}
{{Non-mevalonate pathway enzymes}}
[[Category:EC 2.7.1]]
[[Category:Enzymes of known structure]]

Latest revision as of 22:26, 17 March 2013

Template:Enzyme In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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Template:Enzyme-stub Template:Non-mevalonate pathway enzymes