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The author's title is Christy. I've usually cherished living in Alaska. Doing ballet is some thing she would by no means give up. Invoicing is what I do for a residing but I've usually needed my personal company.<br><br>Here is my blog: free tarot readings ([http://ustanford.com/index.php?do=/profile-38218/info/ http://ustanford.com/index.php?do=/profile-38218/info])
{{enzyme
| Name = GMP synthetase<br />(glutamine-hydrolyzing)
| EC_number = 6.3.5.2
| CAS_number = 37318-71-1
| IUBMB_EC_number = 6/3/5/2
| GO_code = 0003922
| image = PDB_1gpm_EBI.jpg
| width =
| caption = Crystal structure of GMP synthetase.<ref name="pmid8548458">{{cite journal |author=Tesmer JJ, Klem TJ, Deras ML, Davisson VJ, Smith JL |title=The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families |journal=Nat. Struct. Biol. |volume=3 |issue=1 |pages=74–86 |date=January 1996 |pmid=8548458 |doi= 10.1038/nsb0196-74|url=}}</ref>
}}
{{Infobox protein family
| Symbol = GMP_synt_C
| Name = GMP synthetase C terminal domain
| image = PDB 1gpm EBI.jpg
| width =
| caption = escherichia coli gmp synthetase complexed with amp and pyrophosphate
| Pfam = PF00958
| Pfam_clan = 
| InterPro = IPR001674
| SMART =
| PROSITE = PDOC00405
| MEROPS =
| SCOP = 1gpm
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}
{{PBB|geneid=8833}}
'''Guanine monphosphate synthetase''', (EC 6.3.5.2) also known as '''GMPS''' is an [[enzyme]] that converts [[xanthosine monophosphate]] to [[guanosine monophosphate]].<ref name="entrez">{{cite web | title = Entrez Gene: GMPS guanine monphosphate synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8833| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.<ref name="entrez" />
}}
 
==Enzymology==
 
In [[enzymology]], a '''GMP synthetase (glutamine-hydrolysing)''' ({{EC number|6.3.5.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + xanthosine 5'-phosphate + <small>L</small>-glutamine + H<sub>2</sub>O <math>\rightleftharpoons</math> AMP + diphosphate + GMP + <small>L</small>-glutamate
 
The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[xanthosine 5'-phosphate]], [[L-glutamine|<small>L</small>-glutamine]], and [[water|H<sub>2</sub>O]], whereas its 4 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], [[guanosine monophosphate|GMP]], and [[L-glutamate|<small>L</small>-glutamate]].
 
This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor.  The systematic name of this enzyme class is '''xanthosine-5'-phosphate:<small>L</small>-glutamine amido-ligase (AMP-forming)'''. Other names in common use include '''GMP synthetase (glutamine-hydrolysing)''', '''guanylate synthetase (glutamine-hydrolyzing)''', '''guanosine monophosphate synthetase (glutamine-hydrolyzing)''', '''xanthosine 5'-phosphate amidotransferase''', and '''guanosine 5'-monophosphate synthetase'''.  This enzyme participates in [[purine metabolism]] and [[glutamate metabolism]].  At least one compound, [[Psicofuranin]] is known to [[enzyme inhibitor|inhibit this enzyme]].
 
==Structural studies==
 
As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1GPM}}, {{PDB link|1WL8}}, {{PDB link|2A9V}}, {{PDB link|2D7J}}, and {{PDB link|2DPL}}.
 
==References==
{{reflist}}
 
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Page T, Bakay B, Nyhan WL |title=Human GMP synthetase. |journal=Int. J. Biochem. |volume=16 |issue= 1 |pages= 117–20 |year= 1984 |pmid= 6698284 |doi=10.1016/0020-711X(84)90061-2  }}
*{{cite journal  | author=Nakamura J, Straub K, Wu J, Lou L |title=The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23450–5 |year= 1995 |pmid= 7559506 |doi= 10.1074/jbc.270.40.23450 }}
*{{cite journal  | author=Nakamura J, Lou L |title=Biochemical characterization of human GMP synthetase. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7347–53 |year= 1995 |pmid= 7706277 |doi=10.1074/jbc.270.13.7347  }}
*{{cite journal  | author=Hirst M, Haliday E, Nakamura J, Lou L |title=Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. |journal=J. Biol. Chem. |volume=269 |issue= 38 |pages= 23830–7 |year= 1994 |pmid= 8089153 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Fedorova L, Kost-Alimova M, Gizatullin RZ, ''et al.'' |title=Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 2 |pages= 110–6 |year= 1997 |pmid= 9195163 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Pegram LD, Megonigal MD, Lange BJ, ''et al.'' |title=t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene. |journal=Blood |volume=96 |issue= 13 |pages= 4360–2 |year= 2001 |pmid= 11110714 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
}}
* {{cite journal | author = Abrams R and Bentley M | year = 1959 | title = Biosynthesis of nucleic acid purines. III. Guanosine 5'-phosphate formation from xanthosine 5'-phosphate and L-glutamine | journal = Arch. Biochem. Biophys.  | volume = 79 | pages = 91&ndash;110 | doi = 10.1016/0003-9861(59)90383-2 }}
* {{cite journal | author = LAGERKVIST U | year = 1958 | title = Biosynthesis of guanosine 5'-phosphate. II. Amination of xanthosine 5'-phosphate by purified enzyme from pigeon liver | journal = J. Biol. Chem.  | volume = 233 | pages = 143&ndash;9  | pmid = 13563458 | issue = 1 }}
{{refend}}
 
==External links==
* {{MeshName|GMP+synthetase}}
 
{{Ligases}}
{{Nucleotide metabolism}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
{{DEFAULTSORT:GMP synthase (glutamine-hydrolysing)}}
[[Category:EC 6.3.5]]
[[Category:Enzymes of known structure]]
 
 
{{ligase-stub}}

Revision as of 03:10, 17 March 2013

Template:Enzyme Template:Infobox protein family Template:PBB Guanine monphosphate synthetase, (EC 6.3.5.2) also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate.[1]

Template:PBB Summary

Enzymology

In enzymology, a GMP synthetase (glutamine-hydrolysing) (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + xanthosine 5'-phosphate + L-glutamine + H2O AMP + diphosphate + GMP + L-glutamate

The 4 substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

Further reading

Template:Refbegin Template:PBB Further reading

  • One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang
  • One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang

Template:Refend

External links

Template:Ligases Template:Nucleotide metabolism

Template:PBB Controls


Template:Ligase-stub