4-hydroxy-2-oxovalerate aldolase

Template:Enzyme In enzymology, a 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

5-oxopent-3-ene-1,2,5-tricarboxylate $\rightleftharpoons$ 2-oxohept-3-enedioate + CO₂

Hence, this enzyme has one substrate, 5-oxopent-3-ene-1,2,5-tricarboxylate, and two products, 2-oxohept-3-enedioate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming). Other names in common use include 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, and 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase. This enzyme participates in tyrosine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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