Serine—tRNA ligase: Difference between revisions

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| Name = tubulin-tyrosine ligase
| EC_number = 6.3.2.25
| CAS_number = 60321-03-1
| IUBMB_EC_number = 6/3/2/25
| GO_code = 0004835
| image =
| width =
| caption =
}}
In [[enzymology]], a '''tubulin-tyrosine ligase''' ({{EC number|6.3.2.25}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + [[detyrosination|detyrosinated]] alpha-tubulin + L-tyrosine <math>\rightleftharpoons</math> alpha-tubulin + ADP + phosphate
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[detyrosinated alpha-tubulin]], and [[L-tyrosine]], whereas its 3 [[product (chemistry)|products]] are [[alpha-tubulin]], [[adenosine diphosphate|ADP]], and [[phosphate]].
 
This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).  The systematic name of this enzyme class is '''alpha-tubulin:L-tyrosine ligase (ADP-forming)'''.
 
==References==
{{reflist|1}}
* {{cite journal | author = Wehland J, Schroder HC, Weber K | year = 1986 | title = Isolation and purification of tubulin tyrosine ligase | journal = Methods Enzymol. | volume = 134 | pages = 170&ndash;9  | pmid = 3821560 | doi = 10.1016/0076-6879(86)34086-2 }}
* {{cite journal | author = Rudiger M, Wehland J, Weber K | year = 1994 | title = The carboxy-terminal peptide of detyrosinated alpha tubulin provides a minimal system to study the substrate specificity of tubulin-tyrosine ligase | journal = Eur. J. Biochem. | volume = 220 | pages = 309&ndash;20  | pmid = 7510228 | doi = 10.1111/j.1432-1033.1994.tb18627.x | issue = 2 }}
 
{{DEFAULTSORT:Tubulin-tyrosine ligase}}
[[Category:EC 6.3.2]]
[[Category:Enzymes of unknown structure]]
 
 
{{ligase-stub}}

Latest revision as of 16:21, 17 September 2013

Template:Enzyme In enzymology, a tubulin-tyrosine ligase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + detyrosinated alpha-tubulin + L-tyrosine alpha-tubulin + ADP + phosphate

The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).

References

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