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{{enzyme
| Name = aminoacylase
| EC_number = 3.5.1.14
| CAS_number = 9012-37-7
| IUBMB_EC_number = 3/5/1/14
| GO_code = 0004046
| image =
| width =
| caption =
}}
In [[enzymology]], an '''aminoacylase''' ({{EC number|3.5.1.14}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:an N-acyl-L-amino acid + H<sub>2</sub>O <math>\rightleftharpoons</math> a carboxylate + an L-amino acid
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[N-acyl-L-amino acid]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[carboxylate]] and [[L-amino acid]].
 
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is '''N-acyl-L-amino-acid amidohydrolase'''. Other names in common use include '''dehydropeptidase II''', '''histozyme''', '''hippuricase''', '''benzamidase''', '''acylase I''', '''hippurase''', '''amido acid deacylase''', '''L-aminoacylase''', '''acylase''', '''aminoacylase I''', '''L-amino-acid acylase''', '''alpha-N-acylaminoacid hydrolase''', '''long acyl amidoacylase''', and '''short acyl amidoacylase'''. This enzyme participates in [[urea cycle and metabolism of amino groups]].
 
==Structural studies==
 
As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1Q7L}} and {{PDB link|1YSJ}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP | date = 1952 | title = Specificity of amino acid acylases | journal = J. Biol. Chem. | volume = 194 | pages = 455&ndash;70  | pmid = 14927637 | issue = 1 | url=http://www.jbc.org/content/194/1/455.full.pdf | format=PDF }}
* {{cite journal | author = FONES WS, LEE M | date = 1953 | title = Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase | journal = J. Biol. Chem. | volume = 201 | pages = 847&ndash;56  | pmid = 13061423 | issue = 2 | url=http://www.jbc.org/content/201/2/847.full.pdf | format=PDF }}
* {{cite journal | author = Park RW and Fox, SW | date = 1960 | title = An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus | journal = J. Biol. Chem. | volume = 235 | pages = 3193&ndash;3197 | url=http://www.jbc.org/content/235/11/3193.full.pdf | format = PDF | pmid = 13732833 | issue = 11}}
 
{{hydrolase-stub}}
 
[[Category:Hydrolases acting on nonpeptide C-N bonds]]
[[Category:Enzymes of known structure]]

Revision as of 13:55, 13 January 2014

Template:Enzyme In enzymology, an aminoacylase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

an N-acyl-L-amino acid + H2O a carboxylate + an L-amino acid

Thus, the two substrates of this enzyme are N-acyl-L-amino acid and H2O, whereas its two products are carboxylate and L-amino acid.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acyl-L-amino-acid amidohydrolase. Other names in common use include dehydropeptidase II, histozyme, hippuricase, benzamidase, acylase I, hippurase, amido acid deacylase, L-aminoacylase, acylase, aminoacylase I, L-amino-acid acylase, alpha-N-acylaminoacid hydrolase, long acyl amidoacylase, and short acyl amidoacylase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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Template:Hydrolase-stub