3-oxoadipyl-CoA thiolase: Difference between revisions

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{{enzyme
| Name = acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
| EC_number = 2.3.1.129
| CAS_number = 105843-69-4
| IUBMB_EC_number = 2/3/1/129
| GO_code = 0008780
| image =
| width =
| caption =
}}
In [[enzymology]], an '''acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase''' ({{EC number|2.3.1.129}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine <math>\rightleftharpoons</math> [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are (R)-3-hydroxytetradecanoyl-[[acyl-carrier-protein]] and [[UDP-N-acetylglucosamine]], whereas its two [[product (chemistry)|products]] are [[acyl-carrier-protein]] and [[UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase'''. Other names in common use include '''UDP-N-acetylglucosamine acyltransferase''' and '''uridine diphosphoacetylglucosamine acyltransferase'''. This enzyme participates in [[lipopolysaccharide biosynthesis]].
 
==Structural studies==
 
As of late 2007, 7 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1J2Z}}, {{PDB link|1LXA}}, {{PDB link|2AQ9}}, {{PDB link|2JF2}}, {{PDB link|2JF3}}, {{PDB link|2QIA}}, and {{PDB link|2QIV}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Anderson MS, Bulawa CE, Raetz CR | year = 1985 | title = The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli | journal = J. Biol. Chem| volume = 260 | pages = 15536&ndash;41  | pmid = 3905795 | issue = 29 }}
 
{{DEFAULTSORT:Acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase}}
[[Category:EC 2.3.1]]
[[Category:Enzymes of known structure]]
 
 
{{transferase-stub}}

Latest revision as of 21:42, 17 March 2013

Template:Enzyme In enzymology, an acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine

Thus, the two substrates of this enzyme are (R)-3-hydroxytetradecanoyl-acyl-carrier-protein and UDP-N-acetylglucosamine, whereas its two products are acyl-carrier-protein and UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase. Other names in common use include UDP-N-acetylglucosamine acyltransferase and uridine diphosphoacetylglucosamine acyltransferase. This enzyme participates in lipopolysaccharide biosynthesis.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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