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{{enzyme
| Name = aminolevulinate transaminase
| EC_number = 2.6.1.43
| CAS_number = 9012-46-8
| IUBMB_EC_number = 2/6/1/43
| GO_code = 0047665
| image =
| width =
| caption =
}}
In [[enzymology]], an '''aminolevulinate transaminase''' ({{EC number|2.6.1.43}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:5-aminolevulinate + pyruvate <math>\rightleftharpoons</math> 4,5-dioxopentanoate + L-alanine
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[5-aminolevulinate]] and [[pyruvate]], whereas its two [[product (chemistry)|products]] are [[4,5-dioxopentanoate]] and [[L-alanine]].
 
This enzyme belongs to the family of [[transferase]]s, specifically the [[transaminases]], which transfer nitrogenous groups. The systematic name of this enzyme class is '''5-aminolevulinate:pyruvate aminotransferase'''. Other names in common use include '''aminolevulinate aminotransferase, gamma,delta-dioxovalerate''', '''aminotransferase''', '''gamma,delta-dioxovaleric acid transaminase''', '''4,5-dioxovalerate aminotransferase''', '''4,5-dioxovaleric acid transaminase''', '''4,5-dioxovaleric transaminase''', '''5-aminolevulinic acid transaminase''', '''alanine-gamma,delta-dioxovalerate aminotransferase''', '''alanine-dioxovalerate aminotransferase''', '''alanine:4,5-dioxovalerate aminotransferase''', '''aminolevulinic acid transaminase''', '''dioxovalerate transaminase''', '''L-alanine-4,5-dioxovalerate aminotransferase''', '''L-alanine:4,5-dioxovaleric acid transaminase''', '''L-alanine:dioxovalerate transaminase''', '''DOVA transaminase''', and '''4,5-dioxovaleric acid aminotransferase'''.  This enzyme participates in [[porphyrin and chlorophyll metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[pyridoxal phosphate]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Gibson KD, Matthew M and Neuberger A | date = 1961 | title = Biosynthesis of porphyrins and chlorophylls | journal = Nature  | volume = 192 | issue = 4799 | pages = 204&ndash;208 | doi = 10.1038/192204a0 | pmid = 13898421 }}
* {{cite journal | author = NEUBERGER A, TURNER JM | date = 1963 | title = gamma,delta-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides | journal = Biochim. Biophys. Acta. | volume = 67 | pages = 342&ndash;5  | pmid = 13938132 | doi = 10.1016/0006-3002(63)91839-0 }}
 
{{transferase-stub}}
 
[[Category:EC 2.6.1]]
[[Category:Pyridoxal phosphate enzymes]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 02:48, 12 November 2013

Template:Enzyme In enzymology, an aminolevulinate transaminase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

5-aminolevulinate + pyruvate 4,5-dioxopentanoate + L-alanine

Thus, the two substrates of this enzyme are 5-aminolevulinate and pyruvate, whereas its two products are 4,5-dioxopentanoate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminolevulinate:pyruvate aminotransferase. Other names in common use include aminolevulinate aminotransferase, gamma,delta-dioxovalerate, aminotransferase, gamma,delta-dioxovaleric acid transaminase, 4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase, DOVA transaminase, and 4,5-dioxovaleric acid aminotransferase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, pyridoxal phosphate.

References

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Template:Transferase-stub