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| {{Unreferenced|date=December 2009}}
| | Hello, my name is Andrew and my spouse doesn't like it at all. For years he's been living in Alaska and he doesn't plan on changing it. My spouse doesn't like it the way I do but what I truly like performing is caving but I don't have the time lately. Distributing manufacturing is exactly where my primary income arrives from and it's some thing I truly enjoy.<br><br>[http://www.familysurvivalgroup.com/easy-methods-planting-looking-backyard/ love psychics] my blog post; authentic [http://ltreme.com/index.php?do=/profile-127790/info/ psychic solutions by lynne] readings ([http://mybrandcp.com/xe/board_XmDx25/107997 Click On this website]) |
| The '''initial volume of distribution''' is a pharmacological term used to quantify the distribution of a drug throughout the body relatively soon after oral or intravenous dosing of a drug and prior to the drug reaching a steady state equilibrium. Following distribution of the drug, measurement of blood levels indicate the [[apparent volume of distribution]]. Calculation of the initial volume of distribution is the same calculation as that for the apparent volume of distribution, given by the equation:
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| :::::::<math>{V_{D}} = \frac{\mathrm{total \ amount \ of \ drug \ in \ the \ body \ per \ body \ weight \ unit \ (Kg) \ (i.e. Dose)}}{\mathrm{drug \ blood \ concentration}}</math>
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| Therefore the dose required to give a certain plasma concentration can be determined if the V<sub>D</sub> for that drug is known. The V<sub>D</sub> is not a real volume; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc. The V<sub>D</sub> may also be used to determine how readily a drug will displace into the body tissue compartments relative to the blood:
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| :::::::<math>{V_{D}} = {V_{P}} + {V_{T}} \left(\frac{fu}{fu_{t}}\right)</math>
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| Where:
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| V<sub>P</sub> = plasma volume
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| V<sub>T</sub> = apparent tissue volume
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| fu = fraction unbound in plasma
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| fu<sub>T</sub> = fraction unbound in tissue
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| {{Pharmacology}}
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| {{DEFAULTSORT:Initial Volume Of Distribution}}
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| [[Category:Pharmacokinetics]]
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| [[th:ปริมาตรกระจายตัว]]
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Latest revision as of 09:09, 12 September 2014
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