Diphtheria toxin: Difference between revisions

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{{Infobox enzyme
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| Name = DNA-directed DNA polymerase
| EC_number = 2.7.7.7
| CAS_number = 9012-90-2
| IUBMB_EC_number = 2/7/7/7
| GO_code =
| image =
| width =
| caption =
}}
'''DNA-directed DNA polymerase''' ({{EC number|2.7.7.7}}, ''[[DNA polymerase I]]'', ''[[DNA polymerase II]]'', ''[[DNA polymerase III]]'', ''[[DNA polymerase alpha]]'', ''[[DNA polymerase beta]]'', ''DNA polymerase gamma'', ''DNA nucleotidyltransferase (DNA-directed)'', ''DNA nucleotidyltransferase (DNA-directed)'', ''deoxyribonucleate nucleotidyltransferase'', ''deoxynucleate polymerase'', ''deoxyribonucleic acid duplicase'', ''deoxyribonucleic acid polymerase'', ''deoxyribonucleic duplicase'', ''deoxyribonucleic polymerase'', ''deoxyribonucleic polymerase I'', ''DNA duplicase'', ''DNA nucleotidyltransferase'', ''[[DNA polymerase]]'', ''DNA replicase'', ''DNA-dependent DNA polymerase'', ''duplicase'', ''Klenow fragment'', ''sequenase'', ''Taq DNA polymerase'', ''Taq Pol I'', ''Tca DNA polymerase'') is an [[enzyme]] with system name ''deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)''.<ref>{{cite journal | title = Calf thymus polymerase |author = Bollum, F.J. |journal = J. Biol. Chem. |year = 1960 |volume = 235 |pages = 2399–2403 |pmid = 13802334}}</ref><ref>{{cite journal | title = Biochemical studies of bacterial sporulation. II. Deoxy-ribonucleic acid polymerase in spores of <em>Bacillus subtilis</em> |author = Falaschi, A. and Kornberg, A. |journal = J. Biol. Chem. |year = 1966 |volume = 241 |pages = 1478–1482 |pmid = 4957767}}</ref><ref>{{cite journal | title = Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from <em>Escherichia coli</em> |author = Lehman, I.R., Bessman, M.J., Simms, E.S. and Kornberg, A. |journal = J. Biol. Chem. |year = 1958 |volume = 233 |pages = 163–170 |pmid = 13563462}}</ref><ref>{{cite journal | title = Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of <em>Escherichia coli</em> |author = Richardson, C.C., Schildkraut, C.L., Aposhian, H.V. and Kornberg, A. |journal = J. Biol. Chem. |year = 1964 |volume = 239 |pages = 222–232 |pmid = 14114848}}</ref><ref>{{cite journal | title = Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate |author = Schachman, H.K., Adler, J., Radding, C.M., Lehman, I.R. and Kornberg, A. |journal = J. Biol. Chem. |year = 1960 |volume = 235 |pages = 3242–3249 |pmid = 13747134}}</ref><ref>{{cite journal | title = Purification and properties of deoxyribonucleic acid polymerase from <em>Micrococcus lysodeikticus</em> |author = Zimmerman, B.K. |journal = J. Biol. Chem. |year = 1966 |volume = 241 |pages = 2035–2041 |pmid = 5946628}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
 
: [[deoxynucleoside]] triphosphate + DNA<sub>n</sub> <math>\rightleftharpoons</math> [[diphosphate]] + DNA<sub>n+1</sub>
 
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time.
 
== References ==
{{reflist}}
 
== External links ==
* {{MeshName|DNA-directed+DNA+polymerase}}
 
[[Category:EC 2.7.7]]

Revision as of 23:17, 17 February 2014

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