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| A '''multiple of the median''' ('''MoM''') is a measure of how far an individual test result deviates from the [[median]]. MoM is commonly used to report the results of [[Screening (medicine)|medical screening]] tests, particularly where the results of the individual tests are highly [[Statistical dispersion|variable]].<ref>Bishop, J.C.; Dunstan, F.D.; Nix, B.J.; Reynolds, T.M. and Swift, A.; [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1682205 "All MoMs are not equal: some statistical properties associated with reporting results in the form of multiples of the median."] ''Am J Hum Genet.'' 1993 February; 52(2): 425–430.</ref>
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| MoM was originally used as a method to normalize data from participating laboratories of Alpha-fetoprotein (AFP) so that individual test results could be compared. 35 years later, it is the established standard for reporting maternal serum screening results.<ref>Berberich, Stanton L. "Using Multiples of the Median (MoM) for Normalization of TREC Results Meets the Need for Standardized SCID Reporting." http://www.aphl.org/conferences/proceedings/Documents/2013/2013-Newborn-Screening-Symposium/23Berberich.pdf</ref>
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| An MoM for a test result for a patient can be determined by the following:
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| :<math>MoM(Patient) = \frac{Result(Patient)}{Median(PatientPopulation)}</math>
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| As an example, [[Alpha-fetoprotein]] (AFP) testing is used to screen for a [[neural tube defect]] (NTD) during the second trimester of pregnancy. If the median AFP result at 16 weeks of gestation is 30 ng/mL and a pregnant woman's AFP result at that same gestational age is 60 ng/mL, then her MoM is equal to 60/30 = 2.0. In other words, her AFP result is 2 times higher than "normal." <ref>Grenache, David. "Multiple of the Median." http://www.pregnancylab.net/multiple-of-the-median/</ref>
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| ==References==
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| {{reflist}}
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| ==External links==
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| * {{cite web |last= Parvin |first= CA |coauthors= DL Gray and G Kessler |title= Influence of assay method differences on multiple of the median distributions: maternal serum alpha-fetoprotein as an example |work= Clinical Chemistry Vol 37, 637-642 |publisher= American Association for Clinical Chemistry |date= 1991 |url= http://www.clinchem.org/cgi/content/abstract/37/5/637 |accessdate= 2008-02-16}}
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| {{medicine-stub}}
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| [[Category:Medical tests]]
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| [[Category:Medical terminology]]
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| [[Category:Summary statistics]]
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| [[Category:Medical statistics]]
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Latest revision as of 00:57, 2 October 2014
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