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| {{enzyme
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| | Name = 2-hydroxyisoflavanone synthase
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| | EC_number = 1.14.13.86
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| | IUBMB_EC_number = 1/14/13/86
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| In [[enzymology]], a '''2-hydroxyisoflavanone synthase''' ({{EC number|1.14.13.86}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :apigenin + 2 NADPH + 2 H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 2-hydroxy-2,3-dihydrogenistein + 2 NADP<sup>+</sup> + H<sub>2</sub>O
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| The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[apigenin]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[2-hydroxy-2,3-dihydrogenistein]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is '''apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming)'''. This enzyme participates in [[isoflavonoid biosynthesis]].
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| == References ==
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| {{reflist|1}}
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| * {{cite journal | author = Kochs G, Grisebach H | date = 1986 | title = Enzymic synthesis of isoflavones | journal = Eur. J. Biochem. | volume = 155 | pages = 311–8 | pmid = 3956488 | doi = 10.1111/j.1432-1033.1986.tb09492.x | issue = 2 }}
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| * {{cite journal | author = Steele CL, Gijzen M, Qutob D, Dixon RA | date = 1999 | title = Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean | journal = Arch. Biochem. Biophys. | volume = 367 | pages = 146–50 | pmid = 10375412 | doi = 10.1006/abbi.1999.1238 | issue = 1 }}
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| {{1.14.13-enzyme-stub}}
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| [[Category:EC 1.14.13]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:Enzymes of unknown structure]]
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| [[Category:Isoflavonoids metabolism]]
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