|
|
| Line 1: |
Line 1: |
| {{enzyme
| | My namе: Federico Benavidez<br>Age: 34 years old<br>Сountry: United Kingdom<br>Town: Pencader <br>Post code: Sa39 6es<br>Address: 39 Bishopthorpe Road<br><br>My weblog [http://www.forusers.in/groups/vigrx-plus-malaysia-price-getting-tips-to-get-your-nutrition-in-check/ vigrx plus price In karachi] |
| | Name = protein-arginine deiminase
| |
| | EC_number = 3.5.3.15
| |
| | CAS_number = 75536-80-0
| |
| | IUBMB_EC_number = 3/5/3/15
| |
| | GO_code = 0004668
| |
| | image =
| |
| | width =
| |
| | caption =
| |
| }}
| |
| In [[enzymology]], a '''protein-arginine deiminase''' ({{EC number|3.5.3.15}}) is an [[enzyme]] that [[catalysis|catalyzes]] a form of [[post translational modification]] called [[arginine de-imination]] or [[citrullination]]:
| |
| | |
| :protein L-arginine + H<sub>2</sub>O <math>\rightleftharpoons</math> protein L-citrulline + NH<sub>3</sub> | |
| | |
| Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[protein L-arginine]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[protein L-citrulline]] and [[ammonia|NH<sub>3</sub>]].
| |
| | |
| This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is '''protein-L-arginine iminohydrolase'''. This enzyme is also called '''peptidylarginine deiminase'''.
| |
| | |
| ==Structural studies==
| |
| | |
| As of late 2007, 7 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1WD8}}, {{PDB link|1WD9}}, {{PDB link|1WDA}}, {{PDB link|2DEW}}, {{PDB link|2DEX}}, {{PDB link|2DEY}}, and {{PDB link|2DW5}}.
| |
| | |
| ==See also==
| |
| *[[PADI1]]
| |
| *[[PADI2]]
| |
| *[[PADI3]]
| |
| *[[PADI4]]
| |
| | |
| ==References==
| |
| {{reflist|1}}
| |
| * {{cite journal | author = Fujisaki M, Sugawara K | date = Tokyo | title = Properties of peptidylarginine deiminase from the epidermis of newborn rats | journal = J. | volume = Biochem. | pages = 257–63 | pmid = 7217033 | issue = 1 }}
| |
| * {{MeshName|protein-arginine+deiminase}}
| |
| | |
| {{hydrolase-stub}}
| |
| {{Carbon-nitrogen non-peptide hydrolases}}
| |
| [[Category:EC 3.5.3]]
| |
| [[Category:Enzymes of known structure]]
| |
My namе: Federico Benavidez
Age: 34 years old
Сountry: United Kingdom
Town: Pencader
Post code: Sa39 6es
Address: 39 Bishopthorpe Road
My weblog vigrx plus price In karachi