Characteristic |
Description |
Example value |
Symbol |
Formula
|
Dose |
Amount of drug administered. |
500 mg |
|
Design parameter
|
Dosing interval |
Time between drug dose administrations. |
24 h |
|
Design parameter
|
Cmax |
The peak plasma concentration of a drug after administration. |
60.9 mg/L |
|
Direct measurement
|
tmax |
Time to reach Cmax. |
3.9 h |
|
Direct measurement
|
Cmin |
The lowest (trough) concentration that a drug reaches before the next dose is administered. |
27.7 mg/L |
|
Direct measurement
|
Volume of distribution |
The apparent volume in which a drug is distributed (i.e., the parameter relating drug concentration to drug amount in the body). |
6.0 L |
|
|
Concentration |
Amount of drug in a given volume of plasma. |
83.3 mg/L |
|
|
Elimination half-life |
The time required for the concentration of the drug to reach half of its original value. |
12 h |
|
|
Elimination rate constant |
The rate at which a drug is removed from the body. |
0.0578 h−1 |
|
|
Infusion rate |
Rate of infusion required to balance elimination. |
50 mg/h |
|
|
Area under the curve
|
The integral of the concentration-time curve (after a single dose or in steady state).
|
1,320 mg/L·h
|
|
|
|
|
Clearance |
The volume of plasma cleared of the drug per unit time. |
0.38 L/h |
|
|
Bioavailability |
The systemically available fraction of a drug. |
0.8 |
|
|
Fluctuation |
Peak trough fluctuation within one dosing interval at steady state |
41.8 % |
|
where
|
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