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E0 or E00 can refer to :

• Epsilon naught, ε₀, in mathematics, the smallest transfinite ordinal number satisfying ${\epsilon }_0={\omega }^{{\epsilon }_0}$
• Vacuum permittivity, ε₀, in physics, the absolute dielectric permittivity of classical vacuum
• E0 (cipher), a cipher used in the Bluetooth protocol
• E0 (robot), a 1986 humanoid robot by Honda
• Standard electrode potential, E^o, the measure of individual potential of a reversible electrode at standard state
• E0, the digital carrier for audio, specified in G.703
• Eos Airlines IATA code
• E00, Cretinism ICD-10 code