Neutron electric dipole moment
Dextrorotation and levorotation (also spelled laevorotation)[1] refer to the properties of rotating plane polarized light. If the light rotates clockwise as it approaches an observer, this is known as dextrorotation, light with a rotation to the right. If the light rotates counterclockwise as it approaches the observer, then the light exhibits levorotation, rotation to the left.
A compound with dextrorotation is called dextrorotatory or dextrorotary,[2] while a compound with levorotation is called levorotatory or levorotary.[2] Compounds with these properties are said to have optical activity and consist of chiral molecules. If a chiral molecule is dextrorotary, its enantiomer (geometric mirror image) will be levorotary, and vice-versa. In fact, the enantiomers will rotate plane polarized light the same number of degrees, but in opposite directions.
Apart from direct measurement of the optical rotation of an actual sample, it is only possible to determine whether a given chiral molecule will be levorotatory or dextrorotatory, directly from its absolute configuration, via detailed computer modeling.[3] That is to say, both "R" and "S" stereocenters have the ability to be dextrorotatory or levorotatory.
Chirality prefixes
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(+)-, (–)-, d-, l-, D-, and L-
A dextrorotary compound is often prefixed "(+)-" or "d-". Likewise, a levorotary compound is often prefixed "(–)-" or "l-". These "d-" and "l-" prefixes are distinct from the uppercase (though SMALL CAPS) "D-" and "L-" prefixes, which are based on the actual configuration of each enantiomer, with the version synthesized from naturally occurring (+)-glyceraldehyde being considered the D-form. For example, nine of the nineteen L-amino acids commonly found in proteins are dextrorotatory (at a wavelength of 589 nm), and D-fructose is also referred to as levulose because it is levorotatory.
(R)- and (S)-
The (R)- and (S)- prefixes are different from the preceding ones in that the labels R and S characterize the absolute configuration of a specific stereocenter, not a whole molecule. A molecule with just one stereocenter can be labeled R or S, but a molecule with multiple stereocenters needs more than one label, for example (2R,3S).
If there is a pair of enantiomers, each with one stereocenter, then one enantiomer is R and the other is S, and likewise one enantiomer is levorotary and the other is dextrorotary. However, there is no general correlation between these two labels. In some cases the (R)-enantiomer is the dextrorotary enantiomer, and in other cases the (R)-enantiomer is the levorotary enantiomer. The relationship can only be determined on a case-by-case basis with experimental measurements or detailed computer modeling.[3]
Specific rotation
Mining Engineer (Excluding Oil ) Truman from Alma, loves to spend time knotting, largest property developers in singapore developers in singapore and stamp collecting. Recently had a family visit to Urnes Stave Church. A standard measure of the degree to which a compound is dextrorotary or levorotary is the quantity called the specific rotation [α]. Dextrorotary compounds have a positive specific rotation, while levorotary compounds have negative. Two enantiomers have equal and opposite specific rotations.
The formula for specific rotation, [α], is:
where:
- α = observed rotation
- c = concentration of the solution of an enantiomer
- l = length of the tube (polarimeter tube) in decimeters
The degree of rotation of plane-polarized light depends on the number of chiral molecules that it encounters on its way through the tube of polarimeter (thus, the length of the tube and concentration of the enantiomer). In many cases, it also depends on the temperature and the wavelength of light that is employed.
Other terminology
The equivalent French terms are dextrogyre and levogyre. These are occasionally (but very infrequently) used in English.[4]
See also
References
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- ↑ The first word component dextro- comes from Latin word for dexter "right (as opposed to left)". Laevo- or levo- comes from the Latin for laevus, "left side."
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