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Antidepressant drugs for treatment of depression as well as other disorders that may occur alone or in combination with depression, such as chronic pain, sleep disorders, or anxiety disorders. If you are taking an antidepressant, especially if you are under 25, let your doctor know if your depression seems to be getting worse or if you have any thoughts of hurting yourself. If you and your doctor decide that you should try medication for your depression, know that it takes about six weeks for the depression medication to have its full effect. Be sure to discuss any side effects you experience with your doctor.

A major 2006 U.S. government study showed that fewer than 50 percent of people become symptom-free on antidepressants, even after trying two different medications. Other studies show that the benefits of depression medication have been exaggerated, with some researchers concluding that—when it comes to mild to moderate depression—antidepressants are only slightly more effective than placebos. So while drug treatment can be beneficial, it's by no means the only answer.

Spine-Health publishes original articles written for patients by over 100 physician authors and peer-reviewed by a 17 member Medical Advisory Board This trusted, independent site is supported by hundreds of physician members and visited by millions of patients and their physicians. The information in is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding back pain. A depression can range in intensity from mild to severe.

While some people have one episode of depression and then never have another, or remain symptom-free for years, others have more frequent episodes or very long-lasting depressions that may go on for years. Some people find that their depressions become more frequent and severe as they get older. For these people, continuing (maintenance) treatment with antidepressants can be an effective way of reducing the frequency and severity of depressions. But, they do not work in everybody.

More than 60% of Americans taking antidepressant medication have taken it for 2 years or longer, with 14% having taken the medication for 10 years or more. Less than one-third of Americans taking one antidepressant medication and less than one-half of those taking multiple antidepressants have seen a mental health professional in the past year. This data brief discusses all antidepressants taken, regardless of the reason for use. Pharmacoepidemiol Drug Saf 16(5):560-70.

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